Journal of Apicultural Research

 Vol. 46 (2) pp. 94 -98

DOI

10.3896/IBRA.1.46.2.05

Date

June 2007

Article Title

 
Inhibitory effect of bee venom against ultraviolet B induced MMP-1 and MMP-3 in human dermal fibroblasts

Author(s)

SangMi Han, KwangGill Lee, JooHong Yeo, HaeYong Kweon, SoonOk Woo, ManYoung Lee, HaJu Baek and KwanKyu Park

Abstract

Ultraviolet-B (UVB) irradiation induced the synthesis of matrix metalloproteinase-1 (MMP-1) and stromelysin-1 (MMP-3) in skin fibroblasts, causing skin photoaging and skin tumor progression. The effect of honey bee venom (HBV) collected from Apis mellifera on the expression of MMP-1 and MMP-3 in UVB irradiated human dermal fibroblasts (HDF) was investigated. After UVB irradiation, HBV markedly reduced UV-induced MMP-1 by 50 – 80 % and MMP-3 protein levels by 50 – 85 % compared with that of UVBirradiated controls. It also reduced MMP-1 and MMP-3 mRNA expression. Furthermore, HBV accelerated the recovery of the damaged of UVB-irradiated HDF. These results suggest that HBV is a photoprotective agent and could be used as a potential agent in preventing photoaging.

Keywords

bee venom, human dermal fibroblast, UVB irradiation, MMP-1, MMP-3